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Disclosures: Swati Ghosh: Nothing to Disclose, Michael Devereaux: Nothing to Disclose, Karim el kasmi: Nothing to Disclose, Ronald Sokol: Nothing to Disclose 2475 MECHANISM OF STAT3 ROLE IN THE PROTECTIVE EFFECTS OF FXR AGONIST IN CHRONIC MOUSE MODEL OF INFLAMMATORY CHOLANGIOPATHY ♦ Swati Ghosh 1 Michael Devereaux 2 Aimee Anderson 2 David Orlicky 2 Ronald Sokol 1 , 1 University of Colorado School of Medicine, 2 University of Colorado School ofMedicine Background: Primary sclerosing cholangitis (PSC), an inflammatory cholangiopathy, is a chronic liver disease without effective treatments